Also, the magnetic properties of the nanoparticles were studied by squid. Kadirvelu, green synthesis of iron oxide nanoparticles using lagenaria siceraria and evaluation of its antimicrobial activity, defence life science journal, vol. Antibiotics free fulltext iron oxide nanoparticles for. Antimicrobial activity of cerium oxide nanoparticles on. They have emerged as promising candidates to challenge the rising global issue of antimicrobial resistance.
The iron oxide nps came out of synthesis capped with the oleate via a carboxyl group bound to the metal atoms, since iron oleate served as the organometallic metal carbonyl complex by which the iron was delivered to the iron oxide crystal 144,145,146. The antibacterial activity of iron oxide nanoparticles could be due to several mechanisms. Both nanozinc oxide and bulk zinc oxide are 4080fold less toxic than znso 4 against v. Iron oxide nanoparticles were produced by a green and ecofriendly, simple and inexpensive method. The synthesis of iron oxide nanoparticles were validated by uvvisible spectroscopy which showed higher peak at 370 nm as valid standard reference. Synthesis and antibacterial and antibiofilm activity of iron oxide glycerol nanoparticles obtained by coprecipitation method. The results show that mgo np have strong bactericidal activity against the pathogens, achieving more than 7 log reductions in bacterial counts. The findings showed that biogenic iron oxide nanoparticles represent antibacterial activity against e.
Assessment of antimicrobial activity of phytofabricated iron oxide nanoparticles 601 were dried in an furnace at 400c for 2 h, grinded and subjected to characterization, fe 2 o 3 nps synthesis by plant extracts and mixing it with iron nitrate and turning it from yellow to brown forming the iron oxide. These antimicrobial nanoparticles nps may offer advantages in fighting intracellular pathogens as well as biomaterialassociated infections. Biogenic synthesis of magnetic iron oxide nanoparticles using. Jun, 2018 with an increase in antibiotic resistance, a growing interest in developing new antimicrobial agents has gained popularity. Pdf investigating the interaction patterns at nanobio interface is a key challenge for safe use of nanoparticles nps to any biological system. Mallick, 3 krishna pramanik, 2 bibekanand mallick, 1 and suman jha a, 1.
The recovered fungal species from samples included. The iron oxide nanoparticles have a large functional surface to bind, carry and coat other materials1,2. Apr, 2016 generally, nanoparticles with better photocatalytic activity have larger specific surface areas and smaller crystallite sizes, which increase oxygen vacancies, resulting in more ros 31,43. Medical applications and biotechnological advances, including magnetic resonance imaging, cell separation and detection, tissue repair, magnetic hyperthermia and drug delivery, have strongly benefited from employing iron oxide nanoparticles ionps due to their remarkable properties, such as superparamagnetism, size and possibility of receiving a biocompatible coating. The emergence of resistance against antimicrobial agents has led to the development of more efficient agents and new techniques for treatment of various microbial infections. Antimicrobial activity of citric acid functionalized iron. Mar, 2014 the compensation of using these metal oxides nanoparticles as antimicrobial agents is their better efficiency on resistant bacteria, less toxicity and heat resistance, and among metal oxide nanoparticles, zno nanoparticles have many significant features such as chemical and physical stability, high catalysis activity and effective. Antimicrobial activity of chitosan coated iron oxide. Cerium oxide and iron oxide nanoparticles abolish the antibacterial activity of ciprofloxacin against gram positive and gram negative biofilm bacteria.
Department of biotechnology, college of engineering and technology, biju patnaik university of technology. The results indicate that the iron oxide nanoparticles are interesting for potential applications as vector for drug delivery and as constituent of specific platforms for drug targeting. Antibacterial and antifungal activity of chitosan coated. Impact of zinc oxide on biological functions depends on its morphology, particle size, exposure time, concentration, ph, and biocompatibility. The antibacterial activity of iron oxide nanoparticles synthesized by pulsed laser ablation in dmf and sds solutions was investigated against various pathogenic bacteria, using four laser energies 20, 40, 60 and 80 mj. Antimicrobial activity of the metals and metal oxide nanoparticles. Antibacterial activity of iron oxide, iron nitride, and. Artificial cells, nanomedicine, and biotechnology 2017, 45 8, 16991709.
Cerium oxide ceo 2 and iron oxide fe 2 o 3 nanoparticles have been utilized in a number of biomedical applications. Synthesis, characterization, applications, and challenges. The xray diffraction xrd studies demonstrate that gionps were indexed into the spinel cubic lattice with a lattice parameter of 0. This antibacterial activity was identified by well diffusion method as shown in fig. The mechanisms responsible for antibacterial activity of nanomaterials at the molecular level are summarized in figure 1.
Pdf in vitro antimicrobial activity evaluation of metal. The aim of the present study is to determine the antibacterial and antifungal activity of bare and chitosan coated fe3o4 nanoparticles nps against five organisms. Antibiotics free fulltext iron oxide nanoparticles. Express 7 015045 view the article online for updates and enhancements. The glycerol iron oxide nanoparticles gionps were obtained by an adapted coprecipitation method. Zinc oxide is an essential ingredient of many enzymes, sun screens, and ointments for pain and itch relief. The metal oxides, particularly those formed by transition metals are compounds with electronic properties, and most magnetic phenomena involve this type of oxides. Its microcrystals are very efficient light absorbers in the uva and uvb region of spectra due to wide bandgap. Biogenic synthesis of magnetic iron oxide nanoparticles using inedible borassus flabellifer seed coat.
Iron oxide nanoparticles prepared by laser ablation. This enables coating of a spectrum of antimicrobial agents on its surface. Evaluation of antibacterial activity of iron oxide. Jul 20, 2016 we report a robust biofilm with antimicrobial properties fabricated from chitosaniron oxide coated graphene oxide nanocomposite hydrogel. The synthesized nanoparticles exhibit potential antimicrobial efficacies against kleb. Characterization and evaluation of antibacterial activities of chemically synthesized iron oxide nanoparticles. Evaluation of antibacterial activity of iron oxide nanoparticles. The results of zone inhibition method has been described from the fig. Mgo is an important inorganic oxide and has been widely used in many fields. Synthesis, characterisation and antimicrobial activity of.
Pohish journal of chemical technology, 19, 4, 110115, 10. Finally, the formed gel based on iron oxide and silica was dried at room temperature. Pdf antimicrobial potential of iron oxide nanoparticles. In the medical field, research on antimicrobial properties of metal oxide nanoparticles have emerged to find new antimicrobial agents as an alternative against resistant bacteria. Evaluation of antibacterial activity of iron oxide nanoparticles ag ainst escherichia coli mehrdad khatami 1,2, mohammad reza aflatoonian 3, hakim azizi 4. Further its antimicrobial activity against bacillus subtilis and escherichia coli is studied. Oct 15, 2011 the antibacterial activities of magnesium oxide nanoparticles mgo np alone or in combination with other antimicrobials nisin and zno np against escherichia coli o157. Antibacterial activity fe 3o 4 showed antibacterial effect against grampositive as well as gramnegative bacteria which clearly indicates that these nanoparticles are effective antibacterial agents. Nanoparticles with antimicrobial activity are very advantageous in reducing acute toxicity, lowering cost, and overcoming resistance as compared with other prevalent antibiotics 19, 20. Preparation, characterization and antifungal activity of. Antimicrobial activity of iron oxide nanoparticle upon modulation of. Properties of zinc oxide nanoparticles and their activity. The result illustrated that the nanoparticles prepared at 40 ml extract concentration have high antibacterial activity as compared to nanoparticles prepared at 20 ml and 60 ml peel extract.
Easy synthesis and magnetic properties of iron oxide. We report a robust biofilm with antimicrobial properties fabricated from chitosaniron oxide coated graphene oxide nanocomposite hydrogel. Iron oxide nanoparticles for biomedical applications. Nanoparticles nps are at the forefront of rapid development in nanotechnology. Pdf green synthesis of iron oxide nanoparticles using. Iron oxide io nanoparticles were synthesized by co precipitation method as reported by predoi. Chemical preparation of iron oxide nanoparticles using. Iron oxide carbon coreshell nanoparticles for dualmodal imagingguided photothermal therapy. For the synthesis of iron oxide magnetite nps, we have adopted a twostep procedure of park et al. The present study investigates the synthesis and characterization of iron oxide nanoparticles fe 3 o 4nps for their antibacterial potential against bacillus cereus and klebsiella pneumonia by modified disc diffusion and broth agar dilution methods. Metal oxide nanoparticles monpsare known to effectively inhibit the growth of a wide range of grampositive and gramnegative bacteria.
Synthesis and characterization of nanoparticles and nanoparticledrug conjugates. After this, films were fabricated by the gelcasting technique aided. The antibacterial activity was assessed by measuring the zone of inhibition. Dizaj sm, lotfipour f, barzegarjalali m, zarrintan mh, adibkia k. Pdf characterization and evaluation of antibacterial. Antimicrobial activity of citric acid functionalized iron oxide nanoparticles superparamagnetic effect author links open overlay panel sidra khan a zaheer h. Pdf antimicrobial activity of iron oxide nanoparticle upon. The ftir analysis reveals the existence of feo bonding in the synthesized nanoparticles.
Introduction in chemical sciences, synthesis of transition metal and metal oxide nanoparticles is a developing research field. The green synthetic iron oxide nanoparticles have been examined for their antibacterial activity. Academic research paper on topic antibacterial activity of iron oxide nanoparticles synthesized by coprecipitation technology against bacillus cereus and klebsiella pneumoniae. In vitro antimicrobial activity evaluation of metal oxide. Dls and xrd results revealed the average size of synthesized fe 3 o 4nps as 24 nm while xps. Here, the antibacterial activity of ceo 2 and fe 2 o 3 nanoparticles were evaluated on a panel of gram positive and.
The oleate cap was removed with a hydrochloric acid wash. Pdf cerium oxide and iron oxide nanoparticles abolish. The refinement of xrd spectra indicated that no other phases except maghemite were detected. Fe 2 o 3 nanoparticles with three different polysaccharide templates namely cf, saf and pf are successfully synthesized. Antimicrobial activity of iron oxide nanoparticle upon modulation of nanoparticle bacteria interface. Presenting vancomycin on nanoparticles to enhance antimicrobial activities. The higher antibacterial activity of znso 4 is directly proportional to its. Bactericidal effect of iron oxide nanoparticles on staphylococcus aureus. Antibacterial activity of biochemically capped iron oxide. Formulation of iron oxide nanoparticles using exopolysaccharide. Easy preparation of iron oxide nanoparticles 5 and 11nm maghemite. We report a robust biofilm with antimicrobial properties fabricated from chitosan iron oxide coated graphene oxide nanocomposite hydrogel. Bactericidal effect of iron oxide nanoparticles on.
Shah a saira riaz a naveed ahmad b shumaila islam a c m. The synthesis of ironoxide nanoparticles were validated by uvvisible spectroscopy which showed higher peak at 370 nm as valid standard reference. Zinc oxide was combined with iron oxide to produce magnetic composite nanoparticles with improved colloidal aqueous stability and adequate antibacterial activity to prepare the fe oxide nanoparticles, fecl 2 4h 2 o solution was added to a porcine gelatine aqueous solution, followed by addition of a nano 3 solution and allowed to react for 10 min. Evaluation of antibacterial activity of iron oxide nanoparticles against escherichia coli article pdf available december 2017 with 612 reads how we measure reads. Characterization and antibacterial activity of iron oxide nanoparticles 336 synthesis of iron oxide nanoparticles the magnetic nanoparticles synthesized by coprecipitation method specifically based on parameters such as reaction temperature, ph of the suspension, initial molar concentration etc. Synthesis, characterisation and antimicrobial activity of manganese and irondoped zinc oxide nanoparticles neha sharmaa, savita jandaika, sanjeev kumarb, mansi chitkarac and inderjit singh sandhuc adepartment of biotechnology, shoolini university, ba jhol, post of. The main mechanism suggested is the oxidative stress generated by ros. Synthesis of fe3o4 nanoparticles and its antibacterial.
Green synthesis of magnetic iron oxide nanoparticle using. The antimicrobial activity of phyto synthesized iron oxide nanoparticles pion against bacillus sp. Fe 2 o 3 nanoparticles with three different polysaccharide templates namely cf, saf and pf are successfully synthesized via simple thermal decomposition method. For the retrieval and selection of articles, the following keywords were used. Characterization and evaluation of antibacterial activities. Antimicrobial properties of newly developed or modified nanoparticles are usually tested on model bacterial strains such as e. Synthesis of ultra small iron oxide and doped iron oxide. Out of 120 cases of cattle suffering from obvious skin lesions, samples of skin scrapings and hairs from animals were collected. On the other hand, the mbc of iron oxide nanoparticles was calculated at 500 gml. Jan 29, 2020 glycolipid mediated metal nanoparticles silver nanoparticles synthesis was first reported by singh et al. Green synthesized iron nanoparticles in the present study show good antibacterial activity against the human pathogens escherichia coli and staphylococcus aureus. Antibacterial efficacy of ironoxide nanoparticles against. Biogenic synthesis of copper and silver nanoparticles. Biosynthesis and characterization of iron oxide nanoparticles and evaluation of its antimicrobial potential against isolated bacterial and fungal causes of skin affection in cattle were investigated.
This requires the development of nps with high antimicrobial. Synthesis and antibacterial and antibiofilm activity of. Step one is the synthesis of the organic carrier, which delivers the metal atoms individually to the growing lattice. Antimicrobial activity of iron oxide nanoparticle upon modulation of nanoparticlebacteria interface article pdf available in scientific reports 5 october 2015 with 2,267 reads. Release of iron oxide nanoparticle into the environment interact with air, water and soil often causes change in the surface properties of the particles which can. Jun 06, 2012 for example, iron oxide nanoparticles mean average diameter 9 nm, zeta potential under experimental conditions. The antimicrobial activity of the iron oxide, the zinc oxide and the various znfe oxide composite nanoparticles has been examined on two common bacterial pathogens. Antimicrobial activity of iron oxide nanoparticles on staphylococcus aureus was studied by means of mtt assay. The effect of chitosan coated iron oxide nanoparticles was f. Facile one pot greener synthesis of sophorolipid capped gold. The adsorption of glycerol on iron oxide nanoparticles. Antibacterial activity of trimetal cuznfe oxide nanoparticles. Green synthesis of iron oxide nanoparticles using lagenaria siceraria and evaluation of its antimicrobial activity article pdf available november 2017 with.
Antimicrobial activity of zinc and titanium dioxide. Antibacterial and antifungal activity of chitosan coated iron. The structural morphology and magnetic behavior of hematite nanoparticles. An average size of iron oxide nanoparticle found by diffraction light scattering. Metal oxide nanoparticles have been suggested as good candidates for the development of antibacterial agents. Synthesis of iron nanoparticles from aqueous extract of eucalyptus. Antibacterial activity of iron oxide nanoparticles synthesized by coprecipitation technology against bacillus cereus and klebsiella pneumoniae shakeel ahmed ansari shakeel. Antimicrobial activity of iron oxide nanoparticle upon modulation of nanoparticlebacteria interface manoranjan arakha, 1 sweta pal, 1 devyani samantarrai, 1 tapan k.
Pdf evaluation of antibacterial activity of iron oxide. Antibiotics can sustain for long run in the form of nanoparticles than any other large or small molecules 21. Antimicrobial activity of synthesized tio nanoparticles. The synthesis was carried out by coprecipitation of ferrous and ferric ion salts in aqueous solution by adding base at room temperature with flowing n. Further the antibacterial effect of iron oxide nanoparticles was evaluated against ten pathogenic bacteria which showed that the nanoparticles have moderate antibacterial activity against both gram positive and gram negative pathogenic bacterial strains and retains potential application in pharmaceutical and biomedical industries. Subsequently, the antimicrobial activity was evaluated against the. Antimicrobial activity of tio 2 nanoparticles were investigated by well diffusion method against five bacterial strains, e.
Pdf antimicrobial activity of iron oxide nanoparticle. Antibacterial activity of iron oxide nanoparticles synthesized by coprecipitation technology against bacillus cereus and klebsiella pneumoniae. After this, films were fabricated by the gelcasting technique aided by the selfhealing ability of the chitosan. Antibacterial activity of iron oxide nanoparticles. Ewa karwowska antibacterial potential of nanocomposite. Chitosaniron oxide coated graphene oxide nanocomposite. The antimicrobial coating of iron oxide nanoparticles is a possible way to destroy and deactivate the microbes.
Antimicrobial activity of iron oxide nanoparticle upon. Iron nanoparticles with an average size of 21 nm and 32 nm were synthesized using lawsonia inermis and gardenia jasminoides leaves extract, respectively. For the first time, the coprecipitation method was used for the successful synthesis of iron oxide coated graphene oxide gio nanomaterial. Cerium oxide ceo2 and iron oxide fe2o3 nanoparticles have been utilized in a number of biomedical applications. Preparation of iron oxide nanoparticles decorated carbon nanotube using laser ablation in liquid and their antimicrobial activity. Among, the iron oxide nanoparticles have been found to be a promising candidate in nanobiotechnology for wide range of applications including antimicrobial 10, antibiofilm 11, antioxidant 12. In addition, the mechanism of nano antimicrobial action is described and the importance of using in vitro test methods, adopted by leading international regulatory agencies, that can be used to determine the antimicrobial activity of the metal oxide nanoparticles. Superparamagnetic iron oxide nanoparticles spions functionalized with antimicrobial agents are promising infectiontargeted therapeutic platforms when coupled with external magnetic stimuli. High antimicrobial activity and low human cell cytotoxicity. Antimicrobial efficacy of green synthesized iron oxide. Their exclusive sizedependent properties make these materials indispensable and superior in many areas of human activities. Iron oxide io has been widely used in biomedical research because of its biocompatibility and magnetic properties.
Antimicrobial studies on iron oxide nanoparticles in a silica matrix 55 mixture of ferrous chloride tetrahydrate in 2m hcl and ferric chloride hexahydrate was added drop by drop into silica xerogel and stirred for 1h. The iron oxide nanoparticles have been synthesized in coprecipitation method using aqueous solution of ferric and ferrous ions with sodium salt. All english, spanish, and portuguese articles related to the topic that were published from 2006 to october 27, 2016, were selected for analysis. The fesem analysis reveals the nanostructure which is found to be polydispersed bead like agglomerates. In a similar work, reported that iron oxide np posses promising antimicrobial activity against several human pathogens. Propargylated fe 3 o 4 nanoparticles were then synthesized by carbodiimide reaction of propargylamine with the carboxyl groups on the surface of the iron oxide nanoparticles. Holes of 6 mm diameter were punched into the nutrient agar plates.
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